You can slash or bludgeon your enemies to death. You can cast spells to sizzle them to smithereens. Or, you can use poisons, concocted via the Alchemy mechanic, to render them helpless to your assault inOblivion Remastered. The choice is yours, but in truth, the best practice involves doing just that as a secondary tool to hasten the effects of your weapons or magic.
We’ve listed our favourite poisons here, as well as common ingredients which can be used to craft them. You’re going to very quickly notice that nearly all of them include Damage Health, because Damage Health is just that good.

10Damage Health
We’ll start with the quintessential roots of everything else on our list.Damage Healthlowers the target’s health by a number of points dependent on your ingredients, for a number of seconds which are also dictated by your expertise.
There are so many ingredient combinations that can add Damage Health to your poison that it would be a waste to list them all; if you carry so much as a few different things in your inventory, you can commence with the crafting.

9Damage Health + Frost Damage +ShockDamage
Shockis your best Destruction elemental damage source overall, since a fair number of foes are susceptible to it. Fire Damage has its place, but Oblivion Realms are chock-full of enemies that resist it, so a broadly superior secondary element for this nice three-ingredient medley is Frost.
You can craft this potion in several ways, but the easiest ingredients to find (and then combine) are listed below:

8Damage Health +ShockDamage +Silence
Moving down the line with another fairly easy poison to concoct,Damage Health +ShockDamage +Silenceblends our preference forShockDamage withSilence, a terrific debuff which prevents your enemy’s spells from being cast.
There’s nothing more debilitating for a mage than a full stop on the magic front. Even if they have a surprisingly decent melee skill, they’ll still need to get up close and personal to show it, and it’s never going to be sky-high relative to their spellcasting.

7Damage Health + Damage Magicka + Damage Fatigue +Silence
Another, even better, one for disabling a mage’s arsenal,Damage Health + Damage Magicka + Damage Fatigue +Silencewill not only curb their spellcasting ability, but it will also tear apart their magic pool and nuke their melee acumen with a reduced amount of stamina.
6Damage Health + Damage Strength +Paralyze
We’re moving into melee-debilitators now. All those fierce warriors, knights, guards, and other weapon-wielders galore are going to have a hard time inflicting the pain on you withDamage Health + Damage Strength +Paralyze.
Once again, this one’s limited enough in its debuffs to make for a remarkably easy recipe:

5Damage Health + Damage Agility + Damage Strength + Damage Willpower
Next up is an even better melee-stopper.Damage Health + Damage Agility + Damage Strength + Damage Willpoweris good for when you’re up against multiple melee types and want to be able to put a dent in them all: Damage Strength for some weapons, and Damage Agility for others.
Damage Willpower curbs their Fatigue to a degree, but its potency is enhanced with Damage Strength and Damage Agility, leading to a pitiful stamina bar while the effects are active.

4Damage Health + Damage Magicka +Silence+ Damage Willpower + Damage Intelligence
Step aside, earlier mage-wrecker suggestions.Damage Health + Damage Magicka +Silence+ Damage Willpower + Damage Intelligencewill put a severe damper on spell-slinging enemies.Silencestill does the trick, while everything else listed here only furthers the impact.
3Damage Health + Damage Intelligence + Damage Magicka + Damage Willpower +Paralyze
It’s arguable whetherParalyzeis superior toSilence, and - broadly -Silencedoes make more sense for poisoning enemy mages. But withParalyze, you’re preventing the oddballs (often boss-types) who happen to wield significant melee might from simply shrugging off the spell-deafening and ripping you to pieces with good old-fashioned weaponry.
2Damage Health + Damage Magicka + Damage Intelligence +Paralyze+Silence
If you’re looking for a killer cocktail that will completely cancel any magic-centric foe, and why wouldn’t you be, then this is the way to go. TossingParalyzeinto the mix means there’s well and truly nothing they can do to you so long as you keep your distance a bit.
It comes at the “cost” that there are somewhat fewer ingredient combinations available. But there’s still a good deal of variety in the fourth slot - we’ve listed the most common.

1Poisoned Apple
Is it cheating to citePoisoned Appleas the bestpoisonin Oblivion Remastered? Nah, we don’t think so. The recipe is simple as all heck: you don’t use Alchemy. You just acquire the item. It’s also the best poison source in the entire game, so that’s a double whammy.
Getting access to Poison Apples is the more challenging part. But once you have that source, all you need to do is place thePoisoned Applein a non-essential NPC’s pocket, and they’ll die as soon as they eat it.

The only caveat is that they need to not have other food sources first, which means removing foodstuffs from their house if they’re sleeping, or placing thePoisoned Applein their pocket and stealing any other food they happen to have on hand.

